Arkansas State University (A-State) has been awarded a substantial $1.77 million grant from the National Institutes of Health (NIH) to support extensive research into the molecular mechanisms behind tooth decay. This grant, secured by Dr. Robert Shields, an assistant professor of microbiology in the Department of Biological Sciences, marks a significant achievement for the university’s Beck College of Sciences and Mathematics.
Dr. Shields, the principal investigator for the project, pursued funding through the National Institute of Dental and Craniofacial Research, a division of NIH, to advance his research into the causes and effects of tooth decay—a prevalent and costly disease impacting millions across the United States.
“Tooth decay is one of the most widespread diseases, carrying a heavy health and economic burden for the U.S. population,” Dr. Shields emphasized.
The grant will enable Dr. Shields and his multidisciplinary team—including faculty members, doctoral candidates, student researchers, and lab professionals—to explore the intricate molecular processes that drive the evolution and antibiotic resistance of tooth decay-causing pathogens. Dr. Lisa McLellan, a molecular microbiology expert from Purdue University – Fort Wayne, will collaborate on this research, bringing additional expertise from her own lab.
“Our study will focus on the transfer of genetic information between bacteria—a process that not only spreads antibiotic resistance but also accelerates the evolution of pathogens,” Dr. Shields explained. “We aim to understand this phenomenon within the oral cavity and its role in the development of tooth decay.”
The five-year grant will fund the research team’s efforts, including the procurement of chemical reagents, travel expenses for presenting their findings at academic conferences, and other critical expenses tied to the project.
Dr. Jennifer Bouldin, dean of the Beck College of Sciences and Mathematics, highlighted the significance of the NIH R01 grant, describing it as a highly competitive and prestigious award that supports health-related research. “Dr. Shields’ grant is a tremendous opportunity to advance his work in oral health. We are thrilled to see him receive this recognition and look forward to the impact his research will have on this vital area of study,” she said.
Dr. Travis Marsico, vice provost for research, innovation, and discovery, and executive director of the Arkansas Biosciences Institute at A-State, underscored the importance of the NIH R01 grant, often considered the gold standard in human health research funding. “I am thrilled that Dr. Rob Shields has secured this award for his work on dental decay bacteria. The discoveries from this research will have profound implications for basic science and public health, particularly for the people of Arkansas,” Dr. Marsico noted.
This grant is not only a milestone for Dr. Shields but also for A-State, as it represents just the second R01 and the largest NIH award in the university’s history. Dr. Marsico added, “With our recent focus on expanding research development, the goal is to make these kinds of awards more commonplace on campus.”
In a related development, A-State is set to expand its research capabilities further with the launch of the Engagement and Access for Research-Active Institutions (EARA) program in February 2025. This initiative will assist campus researchers in identifying and securing NIH funding opportunities. Fourteen faculty members have already shown interest in participating, with Dr. Shields set to mentor colleagues in their pursuit of NIH funding. His success in securing grants and fostering strong relationships with NIH officials positions him as a valuable leader in this new program.
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